Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia
Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia
About this item
Full title
Author / Creator
Swaminathan, Srividya , Klemm, Lars , Park, Eugene , Papaemmanuil, Elli , Ford, Anthony , Kweon, Soo-Mi , Trageser, Daniel , Hasselfeld, Brian , Henke, Nadine , Mooster, Jana , Geng, Huimin , Schwarz, Klaus , Kogan, Scott C , Casellas, Rafael , Schatz, David G , Lieber, Michael R , Greaves, Mel F and Müschen, Markus
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Secondary mutations can drive the transformation of pre-leukemic clones that carry
ETV6
-
RUNX1
translocations. Müschen and colleagues show that repeated inflammatory episodes induce aberrant coexpression of the DNA recombinases RAG and AID to promote the development of acute lymphoblastic leukemia.
Childhood acute lymphoblastic leuk...
Alternative Titles
Full title
Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4475638
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4475638
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni.3160
