Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mou...
Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma
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Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
The tumor microenvironment is characterized by deficiencies in oxygen and nutrients, such as glucose and amino acids. Activation of the GCN2 arm of the Integrated Stress Response (ISR) in response to amino acid deprivation is one mechanism by which tumor cells cope with nutrient stress. GCN2 phosphorylates the alpha subunit of the eukaryotic transl...
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Full title
Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4485314
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4485314
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep11781
