The putative P‐gp inhibitor telmisartan does not affect the transcellular permeability and cellular...
The putative P‐gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P‐glycoprotein expressing cell line MDCK II MDR1
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United States: John Wiley & Sons, Ltd
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English
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United States: John Wiley & Sons, Ltd
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Verapamil is used in high doses for the treatment of cluster headache. Verapamil has been described as a P‐glycoprotein (P‐gp, ABCB1) substrate. We wished to evaluate in vitro whether co administration of a P‐gp inhibitor with verapamil could be a feasible strategy for increasing CNS uptake of verapamil. Fluxes of radiolabelled verapamil across MDC...
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Full title
The putative P‐gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P‐glycoprotein expressing cell line MDCK II MDR1
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4492727
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4492727
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ISSN
2052-1707
E-ISSN
2052-1707
DOI
10.1002/prp2.151
