A three-step MTOC fragmentation mechanism facilitates bipolar spindle assembly in mouse oocytes
A three-step MTOC fragmentation mechanism facilitates bipolar spindle assembly in mouse oocytes
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Assembly of a bipolar microtubule spindle is essential for accurate chromosome segregation. In somatic cells, spindle bipolarity is determined by the presence of exactly two centrosomes. Remarkably, mammalian oocytes do not contain canonical centrosomes. This study reveals that mouse oocytes assemble a bipolar spindle by fragmenting multiple acentr...
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Full title
A three-step MTOC fragmentation mechanism facilitates bipolar spindle assembly in mouse oocytes
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4501430
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4501430
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms8217
