Crystallographic structure of a small molecule SIRT1 activator-enzyme complex
Crystallographic structure of a small molecule SIRT1 activator-enzyme complex
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Author / Creator
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS) , Dai, Han , Case, April W. , Riera, Thomas V. , Considine, Thomas , Lee, Jessica E. , Hamuro, Yoshitomo , Zhao, Huizhen , Jiang, Yong , Sweitzer, Sharon M. , Pietrak, Beth , Schwartz, Benjamin , Blum, Charles A. , Disch, Jeremy S. , Caldwell, Richard , Szczepankiewicz, Bruce , Oalmann, Christopher , Yee Ng, Pui , White, Brian H. , Casaubon, Rebecca , Narayan, Radha , Koppetsch, Karsten , Bourbonais, Francis , Wu, Bo , Wang, Junfeng , Qian, Dongming , Jiang, Fan , Mao, Cheney , Wang, Minghui , Hu, Erding , Wu, Joe C. , Perni, Robert B. , Vlasuk, George P. and Ellis, James L.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
SIRT1, the founding member of the mammalian family of seven NAD
+
-dependent sirtuins, is composed of 747 amino acids forming a catalytic domain and extended N- and C-terminal regions. We report the design and characterization of an engineered human SIRT1 construct (mini-hSIRT1) containing the minimal structural elements required for lysine d...
Alternative Titles
Full title
Crystallographic structure of a small molecule SIRT1 activator-enzyme complex
Authors, Artists and Contributors
Author / Creator
Dai, Han
Case, April W.
Riera, Thomas V.
Considine, Thomas
Lee, Jessica E.
Hamuro, Yoshitomo
Zhao, Huizhen
Jiang, Yong
Sweitzer, Sharon M.
Pietrak, Beth
Schwartz, Benjamin
Blum, Charles A.
Disch, Jeremy S.
Caldwell, Richard
Szczepankiewicz, Bruce
Oalmann, Christopher
Yee Ng, Pui
White, Brian H.
Casaubon, Rebecca
Narayan, Radha
Koppetsch, Karsten
Bourbonais, Francis
Wu, Bo
Wang, Junfeng
Qian, Dongming
Jiang, Fan
Mao, Cheney
Wang, Minghui
Hu, Erding
Wu, Joe C.
Perni, Robert B.
Vlasuk, George P.
Ellis, James L.
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4506539
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4506539
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms8645
