SARM1 activation triggers axon degeneration locally via NAD+destruction
SARM1 activation triggers axon degeneration locally via NAD+destruction
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Author / Creator
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
United States: American Association for the Advancement of Science
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Scope and Contents
Contents
Axon degeneration is an intrinsic self-destruction program that underlies axon loss during injury and disease. Sterile alpha and TIR motif–containing 1 (SARM1) protein is an essential mediator of axon degeneration. We report that SARM1 initiates a local destruction program involving rapid breakdown of nicotinamide adenine dinucleotide (NAD+) after...
Alternative Titles
Full title
SARM1 activation triggers axon degeneration locally via NAD+destruction
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4513950
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4513950
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1258366
