Cysteine cathepsins are essential in lysosomal degradation of α-synuclein
Cysteine cathepsins are essential in lysosomal degradation of α-synuclein
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
A cellular feature of Parkinson’s disease is cytosolic accumulation and amyloid formation of α-synuclein (α-syn), implicating a misregulation or impairment of protein degradation pathways involving the proteasome and lysosome. Within lysosomes, cathepsin D (CtsD), an aspartyl protease, is suggested to be the main protease for α-syn clearance; howev...
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Full title
Cysteine cathepsins are essential in lysosomal degradation of α-synuclein
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4522768
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4522768
Other Identifiers
ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.1500937112
