Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alc...
Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis
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Author / Creator
Schierwagen, Robert , Maybüchen, Lara , Zimmer, Sebastian , Hittatiya, Kanishka , Bäck, Christer , Klein, Sabine , Uschner, Frank E. , Reul, Winfried , Boor, Peter , Nickenig, Georg , Strassburg, Christian P. , Trautwein, Christian , Plat, Jogchum , Lütjohann, Dieter , Sauerbruch, Tilman , Tacke, Frank and Trebicka, Jonel
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Non-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis, inflammation and fibrosis, which might progress to cirrhosis. Human NASH is associated with metabolic syndrome (MS). Currently, rodent NASH models either lack significant fibrosis or MS. ApoE
−/−
mice are a MS model used in cardiovascular research. The aim of this wor...
Alternative Titles
Full title
Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4531783
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4531783
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep12931
