Loss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition
Loss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition
About this item
Full title
Author / Creator
Russell, Ronan , Perkhofer, Lukas , Liebau, Stefan , Lin, Qiong , Lechel, André , Feld, Fenja M , Hessmann, Elisabeth , Gaedcke, Jochen , Güthle, Melanie , Zenke, Martin , Hartmann, Daniel , von Figura, Guido , Weissinger, Stephanie E , Rudolph, Karl-Lenhard , Möller, Peter , Lennerz, Jochen K , Seufferlein, Thomas , Wagner, Martin and Kleger, Alexander
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Pancreatic ductal adenocarcinoma (PDAC) is associated with accumulation of particular oncogenic mutations and recent genetic sequencing studies have identified ataxia telangiectasia-mutated (ATM) mutations in PDAC cohorts. Here we report that conditional deletion of ATM in a mouse model of PDAC induces a greater number of proliferative precursor le...
Alternative Titles
Full title
Loss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition
Authors, Artists and Contributors
Author / Creator
Perkhofer, Lukas
Liebau, Stefan
Lin, Qiong
Lechel, André
Feld, Fenja M
Hessmann, Elisabeth
Gaedcke, Jochen
Güthle, Melanie
Zenke, Martin
Hartmann, Daniel
von Figura, Guido
Weissinger, Stephanie E
Rudolph, Karl-Lenhard
Möller, Peter
Lennerz, Jochen K
Seufferlein, Thomas
Wagner, Martin
Kleger, Alexander
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4532798
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4532798
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms8677
