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ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis

ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4563676

ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis

About this item

Full title

ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis

Publisher

United States: American Society for Clinical Investigation

Journal title

The Journal of clinical investigation, 2015-07, Vol.125 (7), p.2592-2592

Language

English

Formats

Publication information

Publisher

United States: American Society for Clinical Investigation

More information

Scope and Contents

Contents

The integrated stress response (ISR) is a critical mediator of cancer cell survival, and targeting the ISR inhibits tumor progression. Here, we have shown that activating transcription factor 4 (ATF4), a master transcriptional effector of the ISR, protects transformed cells against anoikis - a specialized form of apoptosis - following matrix detach...

Alternative Titles

Full title

ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4563676

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4563676

Other Identifiers

ISSN

0021-9738

E-ISSN

1558-8238

DOI

10.1172/JCI78031

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