An atomic structure of human γ-secretase
An atomic structure of human γ-secretase
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Dysfunction of the intramembrane protease γ-secretase is thought to cause Alzheimer’s disease, with most mutations derived from Alzheimer’s disease mapping to the catalytic subunit presenilin 1 (PS1). Here we report an atomic structure of human γ-secretase at 3.4 Å resolution, determined by single-particle cryo-electron microscopy. Mutations derive...
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An atomic structure of human γ-secretase
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4568306
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4568306
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature14892
