Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally...
Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The MERS-CoV is an emerging virus, which already infected more than 1,300 humans with high (∼36%) mortality. Here, we show that m336, an exceptionally potent human anti-MERS-CoV antibody, is almost germline with only one somatic mutation in the heavy chain. The structure of Fab m336 in complex with the MERS-CoV receptor-binding domain reveals that...
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Full title
Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4571279
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4571279
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms9223
