Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pat...
Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology
About this item
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Author / Creator
Clayton, Emma L. , Mizielinska, Sarah , Edgar, James R. , Nielsen, Troels Tolstrup , Marshall, Sarah , Norona, Frances E. , Robbins, Miranda , Damirji, Hana , Holm, Ida E. , Johannsen, Peter , Nielsen, Jørgen E. , Asante, Emmanuel A. , Collinge, John , Isaacs, Adrian M. , FReJA consortium and The FReJA consortium
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
Mutations in the charged multivesicular body protein 2B (
CHMP2B
) cause frontotemporal dementia (FTD). We report that mice which express FTD-causative mutant CHMP2B at physiological levels develop a novel lysosomal storage pathology characterised by large neuronal autofluorescent aggregates. The aggregates are an early and progressive pathol...
Alternative Titles
Full title
Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4575387
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4575387
Other Identifiers
ISSN
0001-6322
E-ISSN
1432-0533
DOI
10.1007/s00401-015-1475-3
