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NSAIDs Ibuprofen, Indometacin and Diclofenac do not interact with Farnesoid X Receptor

NSAIDs Ibuprofen, Indometacin and Diclofenac do not interact with Farnesoid X Receptor

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4589779

NSAIDs Ibuprofen, Indometacin and Diclofenac do not interact with Farnesoid X Receptor

About this item

Full title

NSAIDs Ibuprofen, Indometacin and Diclofenac do not interact with Farnesoid X Receptor

Publisher

London: Nature Publishing Group UK

Journal title

Scientific reports, 2015-10, Vol.5 (1), p.14782, Article 14782

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

The nuclear farnesoid X receptor (FXR) is a ligand activated transcription factor and acts as cellular sensor for bile acids. In this role, FXR is a highly important liver protector and FXR inhibition by antagonists or knockout has shown several deleterious effects. A recent report characterized non-steroidal anti-rheumatic drugs (NSAIDs) such as i...

Alternative Titles

Full title

NSAIDs Ibuprofen, Indometacin and Diclofenac do not interact with Farnesoid X Receptor

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4589779

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4589779

Other Identifiers

ISSN

2045-2322

E-ISSN

2045-2322

DOI

10.1038/srep14782

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