Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 a...
Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins
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Publisher
England: Nature Publishing Group
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Language
English
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England: Nature Publishing Group
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Contents
LC3-associated phagocytosis (LAP) is a process wherein elements of autophagy conjugate LC3 to phagosomal membranes. We characterize the molecular requirements for LAP, and identify Rubicon as being required for LAP but not autophagy. Rubicon is recruited to LAPosomes and is required for the activity of a Class III PI(3)K complex containing UVRAG bu...
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Full title
Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4612372
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4612372
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb3192
