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Role of Tet1 and 5-hydroxymethylcytosine in cocaine action

Role of Tet1 and 5-hydroxymethylcytosine in cocaine action

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4617315

Role of Tet1 and 5-hydroxymethylcytosine in cocaine action

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Publication information

Publisher

New York: Nature Publishing Group US

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Scope and Contents

Contents

Expression of TET1 dioxygenase, which catalyzes the conversion of 5-methylcytosine to 5-hydroxymethylcytosine, is downregulated by repeated cocaine administration in mouse nucleus accumbens, where it controls cocaine reward. Genome-wide mapping of 5-hydroxymethylcytosine in this brain region reveals novel modes of epigenetic regulation by cocaine.<...

Alternative Titles

Full title

Role of Tet1 and 5-hydroxymethylcytosine in cocaine action

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Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4617315

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4617315

Other Identifiers

ISSN

1097-6256

E-ISSN

1546-1726

DOI

10.1038/nn.3976

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