Highly encephalitogenic aquaporin 4-specific T cells and NMO-IgG jointly orchestrate lesion location...
Highly encephalitogenic aquaporin 4-specific T cells and NMO-IgG jointly orchestrate lesion location and tissue damage in the CNS
About this item
Full title
Author / Creator
Zeka, Bleranda , Hastermann, Maria , Hochmeister, Sonja , Kögl, Nikolaus , Kaufmann, Nathalie , Schanda, Kathrin , Mader, Simone , Misu, Tatsuro , Rommer, Paulus , Fujihara, Kazuo , Illes, Zsolt , Leutmezer, Fritz , Sato, Douglas Kazutoshi , Nakashima, Ichiro , Reindl, Markus , Lassmann, Hans and Bradl, Monika
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
In neuromyelitis optica (NMO), astrocytes become targets for pathogenic aquaporin 4 (AQP4)-specific antibodies which gain access to the central nervous system (CNS) in the course of inflammatory processes. Since these antibodies belong to a T cell-dependent subgroup of immunoglobulins, and since NMO lesions contain activated CD4
+
T cells, th...
Alternative Titles
Full title
Highly encephalitogenic aquaporin 4-specific T cells and NMO-IgG jointly orchestrate lesion location and tissue damage in the CNS
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4654751
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4654751
Other Identifiers
ISSN
0001-6322
E-ISSN
1432-0533
DOI
10.1007/s00401-015-1501-5
