High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for prot...
High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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The matrix 2 (M2) protein from influenza A virus is a proton channel that uses His37 as a selectivity filter. Here we report high-resolution (1.10 Å) cryogenic crystallographic structures of the transmembrane domain of M2 at low and high pH. These structures reveal that waters within the pore form hydrogen-bonded networks or “water wires” spanning...
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Full title
High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4655559
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4655559
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1518493112
