G9a is essential for epigenetic silencing of K+ channel genes in acute-to-chronic pain transition
G9a is essential for epigenetic silencing of K+ channel genes in acute-to-chronic pain transition
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Chronic neuropathic pain is associated with K
+
channel downregulation in primary sensory neurons. The authors show that G9a, a histone-modifying enzyme, is required for transcriptional repression of K
+
channel–associated gene families caused by nerve injury. G9a in primary sensory neurons is a key epigenetic regulator involved in acut...
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Full title
G9a is essential for epigenetic silencing of K+ channel genes in acute-to-chronic pain transition
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4661086
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4661086
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.4165
