Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered g...
Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes
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Author / Creator
Sanborn, Adrian L. , Rao, Suhas S. P. , Huang, Su-Chen , Durand, Neva C. , Huntley, Miriam H. , Jewett, Andrew I. , Bochkov, Ivan D. , Chinnappan, Dharmaraj , Cutkosky, Ashok , Li, Jian , Geeting, Kristopher P. , Gnirke, Andreas , Melnikov, Alexandre , McKenna, Doug , Stamenova, Elena K. , Lander, Eric S. and Aiden, Erez Lieberman
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
We recently used in situ Hi-C to create kilobase-resolution 3D maps of mammalian genomes. Here, we combine these maps with new Hi-C, microscopy, and genome-editing experiments to study the physical structure of chromatin fibers, domains, and loops. We find that the observed contact domains are inconsistent with the equilibrium state for an ordinary...
Alternative Titles
Full title
Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4664323
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4664323
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1518552112
