SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes
SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes
About this item
Full title
Author / Creator
Tajima, Ken , Yae, Toshifumi , Javaid, Sarah , Tam, Oliver , Comaills, Valentine , Morris, Robert , Wittner, Ben S. , Liu, Mingzhu , Engstrom, Amanda , Takahashi, Fumiyuki , Black, Joshua C. , Ramaswamy, Sridhar , Shioda, Toshihiro , Hammell, Molly , Haber, Daniel A. , Whetstine, Johnathan R. and Maheswaran, Shyamala
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Expression of the p53-inducible antiproliferative gene
BTG2
is suppressed in many cancers in the absence of inactivating gene mutations, suggesting alternative mechanisms of silencing. Using a shRNA screen targeting 43 histone lysine methyltransferases (KMTs), we show that SETD1A suppresses BTG2 expression through its induction of several BTG...
Alternative Titles
Full title
SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4667427
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4667427
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms9257
