miRNA–target chimeras reveal miRNA 3′-end pairing as a major determinant of Argonaute target specifi...
miRNA–target chimeras reveal miRNA 3′-end pairing as a major determinant of Argonaute target specificity
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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microRNAs (miRNAs) act as sequence-specific guides for Argonaute (AGO) proteins, which mediate posttranscriptional silencing of target messenger RNAs. Despite their importance in many biological processes, rules governing AGO–miRNA targeting are only partially understood. Here we report a modified AGO HITS-CLIP strategy termed CLEAR (covalent ligat...
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miRNA–target chimeras reveal miRNA 3′-end pairing as a major determinant of Argonaute target specificity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4674787
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4674787
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms9864
