The experimental power of FR900359 to study Gq-regulated biological processes
The experimental power of FR900359 to study Gq-regulated biological processes
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Author / Creator
Schrage, Ramona , Schmitz, Anna-Lena , Gaffal, Evelyn , Annala, Suvi , Kehraus, Stefan , Wenzel, Daniela , Büllesbach, Katrin M. , Bald, Tobias , Inoue, Asuka , Shinjo, Yuji , Galandrin, Ségolène , Shridhar, Naveen , Hesse, Michael , Grundmann, Manuel , Merten, Nicole , Charpentier, Thomas H. , Martz, Matthew , Butcher, Adrian J. , Slodczyk, Tanja , Armando, Sylvain , Effern, Maike , Namkung, Yoon , Jenkins, Laura , Horn, Velten , Stößel, Anne , Dargatz, Harald , Tietze, Daniel , Imhof, Diana , Galés, Céline , Drewke, Christel , Müller, Christa E. , Hölzel, Michael , Milligan, Graeme , Tobin, Andrew B. , Gomeza, Jesús , Dohlman, Henrik G. , Sondek, John , Harden, T. Kendall , Bouvier, Michel , Laporte, Stéphane A. , Aoki, Junken , Fleischmann, Bernd K. , Mohr, Klaus , König, Gabriele M. , Tüting, Thomas and Kostenis, Evi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Despite the discovery of heterotrimeric αβγ G proteins ∼25 years ago, their selective perturbation by cell-permeable inhibitors remains a fundamental challenge. Here we report that the plant-derived depsipeptide FR900359 (FR) is ideally suited to this task. Using a multifaceted approach we systematically characterize FR as a selective inhibitor of...
Alternative Titles
Full title
The experimental power of FR900359 to study Gq-regulated biological processes
Authors, Artists and Contributors
Author / Creator
Schmitz, Anna-Lena
Gaffal, Evelyn
Annala, Suvi
Kehraus, Stefan
Wenzel, Daniela
Büllesbach, Katrin M.
Bald, Tobias
Inoue, Asuka
Shinjo, Yuji
Galandrin, Ségolène
Shridhar, Naveen
Hesse, Michael
Grundmann, Manuel
Merten, Nicole
Charpentier, Thomas H.
Martz, Matthew
Butcher, Adrian J.
Slodczyk, Tanja
Armando, Sylvain
Effern, Maike
Namkung, Yoon
Jenkins, Laura
Horn, Velten
Stößel, Anne
Dargatz, Harald
Tietze, Daniel
Imhof, Diana
Galés, Céline
Drewke, Christel
Müller, Christa E.
Hölzel, Michael
Milligan, Graeme
Tobin, Andrew B.
Gomeza, Jesús
Dohlman, Henrik G.
Sondek, John
Harden, T. Kendall
Bouvier, Michel
Laporte, Stéphane A.
Aoki, Junken
Fleischmann, Bernd K.
Mohr, Klaus
König, Gabriele M.
Tüting, Thomas
Kostenis, Evi
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4682109
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4682109
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms10156
