Are sirtuins viable targets for improving healthspan and lifespan?
Are sirtuins viable targets for improving healthspan and lifespan?
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Key Points
Caloric restriction is known to retard ageing and delay functional decline as well as the onset of disease in most organisms.
Mammalian sirtuins (SIRT1–SIRT7) have roles in nutrient sensing, energy metabolism and genome stability, and may mediate some of the effects of caloric restriction.
Sirtuin 1 (SIRT1), the most studied of...
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Full title
Are sirtuins viable targets for improving healthspan and lifespan?
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4684642
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4684642
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ISSN
1474-1776
E-ISSN
1474-1784
DOI
10.1038/nrd3738
