Vinculin controls talin engagement with the actomyosin machinery
Vinculin controls talin engagement with the actomyosin machinery
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The link between extracellular-matrix-bound integrins and intracellular F-actin is essential for cell spreading and migration. Here, we demonstrate how the actin-binding proteins talin and vinculin cooperate to provide this link. By expressing structure-based talin mutants in talin null cells, we show that while the C-terminal actin-binding site (A...
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Full title
Vinculin controls talin engagement with the actomyosin machinery
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4686655
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4686655
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms10038
