MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline...
MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer’s disease
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Author / Creator
Baranger, Kévin , Marchalant, Yannick , Bonnet, Amandine E , Crouzin, Nadine , Carrete, Alex , Paumier, Jean-Michel , Py, Nathalie A , Bernard, Anne , Bauer, Charlotte , Charrat, Eliane , Moschke, Katrin , Seiki, Mothoharu , Vignes, Michel , Lichtenthaler, Stefan F , Checler, Frédéric , Khrestchatisky, Michel and Rivera, Santiago
Publisher
Cham: Springer International Publishing
Journal title
Language
English
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Publisher
Cham: Springer International Publishing
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Scope and Contents
Contents
Membrane-type 5-matrix metalloproteinase (MT5-MMP) is a proteinase mainly expressed in the nervous system with emerging roles in brain pathophysiology. The implication of MT5-MMP in Alzheimer’s disease (AD), notably its interplay with the amyloidogenic process, remains elusive. Accordingly, we crossed the genetically engineered 5xFAD mouse model of...
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Full title
MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer’s disease
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4700096
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4700096
Other Identifiers
ISSN
1420-682X
E-ISSN
1420-9071
DOI
10.1007/s00018-015-1992-1
