A novel multiple-stage antimalarial agent that inhibits protein synthesis
A novel multiple-stage antimalarial agent that inhibits protein synthesis
About this item
Full title
Author / Creator
Baragaña, Beatriz , Hallyburton, Irene , Lee, Marcus C. S. , Norcross, Neil R. , Grimaldi, Raffaella , Otto, Thomas D. , Proto, William R. , Blagborough, Andrew M. , Meister, Stephan , Wirjanata, Grennady , Ruecker, Andrea , Upton, Leanna M. , Abraham, Tara S. , Almeida, Mariana J. , Pradhan, Anupam , Porzelle, Achim , Martínez, María Santos , Bolscher, Judith M. , Woodland, Andrew , Luksch, Torsten , Norval, Suzanne , Zuccotto, Fabio , Thomas, John , Simeons, Frederick , Stojanovski, Laste , Osuna-Cabello, Maria , Brock, Paddy M. , Churcher, Tom S. , Sala, Katarzyna A. , Zakutansky, Sara E. , Jiménez-Díaz, María Belén , Sanz, Laura Maria , Riley, Jennifer , Basak, Rajshekhar , Campbell, Michael , Avery, Vicky M. , Sauerwein, Robert W. , Dechering, Koen J. , Noviyanti, Rintis , Campo, Brice , Frearson, Julie A. , Angulo-Barturen, Iñigo , Ferrer-Bazaga, Santiago , Gamo, Francisco Javier , Wyatt, Paul G. , Leroy, Didier , Siegl, Peter , Delves, Michael J. , Kyle, Dennis E. , Wittlin, Sergio , Marfurt, Jutta , Price, Ric N. , Sinden, Robert E. , Winzeler, Elizabeth A. , Charman, Susan A. , Bebrevska, Lidiya , Gray, David W. , Campbell, Simon , Fairlamb, Alan H. , Willis, Paul A. , Rayner, Julian C. , Fidock, David A. , Read, Kevin D. and Gilbert, Ian H.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
There is an urgent need for new drugs to treat malaria, with broad therapeutic potential and novel modes of action, to widen the scope of treatment and to overcome emerging drug resistance. Here we describe the discovery of DDD107498, a compound with a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the
P...
Alternative Titles
Full title
A novel multiple-stage antimalarial agent that inhibits protein synthesis
Authors, Artists and Contributors
Author / Creator
Hallyburton, Irene
Lee, Marcus C. S.
Norcross, Neil R.
Grimaldi, Raffaella
Otto, Thomas D.
Proto, William R.
Blagborough, Andrew M.
Meister, Stephan
Wirjanata, Grennady
Ruecker, Andrea
Upton, Leanna M.
Abraham, Tara S.
Almeida, Mariana J.
Pradhan, Anupam
Porzelle, Achim
Martínez, María Santos
Bolscher, Judith M.
Woodland, Andrew
Luksch, Torsten
Norval, Suzanne
Zuccotto, Fabio
Thomas, John
Simeons, Frederick
Stojanovski, Laste
Osuna-Cabello, Maria
Brock, Paddy M.
Churcher, Tom S.
Sala, Katarzyna A.
Zakutansky, Sara E.
Jiménez-Díaz, María Belén
Sanz, Laura Maria
Riley, Jennifer
Basak, Rajshekhar
Campbell, Michael
Avery, Vicky M.
Sauerwein, Robert W.
Dechering, Koen J.
Noviyanti, Rintis
Campo, Brice
Frearson, Julie A.
Angulo-Barturen, Iñigo
Ferrer-Bazaga, Santiago
Gamo, Francisco Javier
Wyatt, Paul G.
Leroy, Didier
Siegl, Peter
Delves, Michael J.
Kyle, Dennis E.
Wittlin, Sergio
Marfurt, Jutta
Price, Ric N.
Sinden, Robert E.
Winzeler, Elizabeth A.
Charman, Susan A.
Bebrevska, Lidiya
Gray, David W.
Campbell, Simon
Fairlamb, Alan H.
Willis, Paul A.
Rayner, Julian C.
Fidock, David A.
Read, Kevin D.
Gilbert, Ian H.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4700930
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4700930
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature14451
