Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells
Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells
About this item
Full title
Author / Creator
Publisher
United States: Elsevier B.V
Journal title
Language
English
Formats
Publication information
Publisher
United States: Elsevier B.V
Subjects
More information
Scope and Contents
Contents
BRAF inhibitors can extend progression-free and overall survival in melanoma patients whose tumors harbor mutations in BRAF. However, the majority of patients eventually develop resistance to these drugs. Here we show that BRAF mutant melanoma cells that have developed acquired resistance to BRAF inhibitors display increased oxidative metabolism an...
Alternative Titles
Full title
Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4717845
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4717845
Other Identifiers
ISSN
1574-7891
E-ISSN
1878-0261
DOI
10.1016/j.molonc.2015.08.003
