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Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells

Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4717845

Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells

About this item

Full title

Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells

Publisher

United States: Elsevier B.V

Journal title

Molecular oncology, 2016-01, Vol.10 (1), p.73-84

Language

English

Formats

Publication information

Publisher

United States: Elsevier B.V

More information

Scope and Contents

Contents

BRAF inhibitors can extend progression-free and overall survival in melanoma patients whose tumors harbor mutations in BRAF. However, the majority of patients eventually develop resistance to these drugs. Here we show that BRAF mutant melanoma cells that have developed acquired resistance to BRAF inhibitors display increased oxidative metabolism an...

Alternative Titles

Full title

Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4717845

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4717845

Other Identifiers

ISSN

1574-7891

E-ISSN

1878-0261

DOI

10.1016/j.molonc.2015.08.003

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