A spectral approach integrating functional genomic annotations for coding and noncoding variants
A spectral approach integrating functional genomic annotations for coding and noncoding variants
About this item
Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Iuliana Ionita-Laza, Kenneth McCallum and colleagues developed an unsupervised statistical approach, Eigen, that integrates different functional annotations into a single measure of functional importance for coding and noncoding variants. Their meta-score can outperform the recently proposed CADD score and can be applied to fine-mapping studies.
Alternative Titles
Full title
A spectral approach integrating functional genomic annotations for coding and noncoding variants
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4731313
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4731313
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.3477
