Proton-gated Ca2+-permeable TRP channels damage myelin in conditions mimicking ischaemia
Proton-gated Ca2+-permeable TRP channels damage myelin in conditions mimicking ischaemia
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Ischaemia damages nerve myelin by depriving neurons and their myelinating oligodendrocytes of oxygen and glucose; here it is shown that ischaemic damage is caused through the H
+
-dependent activation of TRPA1 channels, and not via glutamate receptors of the NMDA type, as previously thought, providing a new mechanism and promising therapeutic...
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Full title
Proton-gated Ca2+-permeable TRP channels damage myelin in conditions mimicking ischaemia
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4733665
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4733665
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature16519
