Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contrib...
Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Lupus-like disease is driven by NETs enriched in mitochondrial DNA.
Neutrophil extracellular traps (NETs) are implicated in autoimmunity, but how they are generated and their roles in sterile inflammation remain unclear. Ribonucleoprotein immune complexes (RNP ICs), inducers of NETosis, require mitochondrial reactive oxygen species (ROS) for max...
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Full title
Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4742415
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4742415
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4027
