CAUSEL: An epigenome and genome editing pipeline for establishing function of non-coding GWAS varian...
CAUSEL: An epigenome and genome editing pipeline for establishing function of non-coding GWAS variants
About this item
Full title
Author / Creator
Spisak, Sandor , Lawrenson, Kate , Fu, Yanfang , Csabai, Istvan , Cottman, Rebecca T. , Haiman, Christopher , Han, Ying , Seo, Ji-Heui , Lenci, Romina , Li, Qiyuan , Tisza, Viktoria , Szallasi, Zoltan , Herbert, Zachery T. , Chabot, Matthew , Pomerantz, Mark , Solymosi, Norbert , Gayther, Simon , Joung, J. Keith and Freedman, Matthew L.
Journal title
Language
English
Formats
More information
Scope and Contents
Contents
The vast majority of disease-associated single nucleotide polymorphisms (SNPs) mapped by genome-wide association studies (GWAS) are located in the non-protein coding genome, but establishing the functional and mechanistic roles of these sequence variants has proven challenging. Here, we describe a general pipeline in which candidate functional SNPs...
Alternative Titles
Full title
CAUSEL: An epigenome and genome editing pipeline for establishing function of non-coding GWAS variants
Authors, Artists and Contributors
Author / Creator
Lawrenson, Kate
Fu, Yanfang
Csabai, Istvan
Cottman, Rebecca T.
Haiman, Christopher
Han, Ying
Seo, Ji-Heui
Lenci, Romina
Li, Qiyuan
Tisza, Viktoria
Szallasi, Zoltan
Herbert, Zachery T.
Chabot, Matthew
Pomerantz, Mark
Solymosi, Norbert
Gayther, Simon
Joung, J. Keith
Freedman, Matthew L.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4746056
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4746056
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3975
