Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD
Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD
About this item
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Author / Creator
Boeynaems, Steven , Bogaert, Elke , Michiels, Emiel , Gijselinck, Ilse , Sieben, Anne , Jovičić, Ana , De Baets, Greet , Scheveneels, Wendy , Steyaert, Jolien , Cuijt, Ivy , Verstrepen, Kevin J. , Callaerts, Patrick , Rousseau, Frederic , Schymkowitz, Joost , Cruts, Marc , Van Broeckhoven, Christine , Van Damme, Philip , Gitler, Aaron D. , Robberecht, Wim and Van Den Bosch, Ludo
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Hexanucleotide repeat expansions in
C9orf72
are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD) (c9ALS/FTD). Unconventional translation of these repeats produces dipeptide repeat proteins (DPRs) that may cause neurodegeneration. We performed a modifier screen in
Drosophila
and discovere...
Alternative Titles
Full title
Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD
Authors, Artists and Contributors
Author / Creator
Bogaert, Elke
Michiels, Emiel
Gijselinck, Ilse
Sieben, Anne
Jovičić, Ana
De Baets, Greet
Scheveneels, Wendy
Steyaert, Jolien
Cuijt, Ivy
Verstrepen, Kevin J.
Callaerts, Patrick
Rousseau, Frederic
Schymkowitz, Joost
Cruts, Marc
Van Broeckhoven, Christine
Van Damme, Philip
Gitler, Aaron D.
Robberecht, Wim
Van Den Bosch, Ludo
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4751451
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4751451
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep20877
