Development of Novel Adenoviral Vectors to Overcome Challenges Observed With HAdV-5–based Constructs
Development of Novel Adenoviral Vectors to Overcome Challenges Observed With HAdV-5–based Constructs
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Publisher
United States: Elsevier Inc
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Language
English
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Publisher
United States: Elsevier Inc
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Contents
Recombinant vectors based on human adenovirus serotype 5 (HAdV-5) have been extensively studied in preclinical models and clinical trials over the past two decades. However, the thorough understanding of the HAdV-5 interaction with human subjects has uncovered major concerns about its product applicability. High vector-associated toxicity and wides...
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Full title
Development of Novel Adenoviral Vectors to Overcome Challenges Observed With HAdV-5–based Constructs
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4754553
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4754553
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ISSN
1525-0016
E-ISSN
1525-0024
DOI
10.1038/mt.2015.194
