Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unf...
Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response
About this item
Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
The transcription factor Blimp-1 is required for the differentiation of activated B cells into plasmablasts. Nutt and colleagues show that plasma cells need Blimp-1 to maintain antibody production by regulating the kinase mTOR and unfolded-protein-response pathways.
Plasma cell differentiation requires silencing of B cell transcription, while it...
Alternative Titles
Full title
Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4757736
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4757736
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni.3348
