Clonally expanded CD4⁺ T cells can produce infectious HIV-1 in vivo
Clonally expanded CD4⁺ T cells can produce infectious HIV-1 in vivo
About this item
Full title
Author / Creator
Simonetti, Francesco R. , Sobolewski, Michele D. , Fyne, Elizabeth , Shao, Wei , Spindler, Jonathan , Hattori, Junko , Anderson, Elizabeth M. , Watters, Sarah A. , Hill, Shawn , Wu, Xiaolin , Wells, David , Su, Li , Luke, Brian T. , Halvas, Elias K. , Besson, Guillaume , Penrose, Kerri J. , Yang, Zhiming , Kwan, Richard W. , Van Waes, Carter , Uldrick, Thomas , Citrin, Deborah E. , Kovacs, Joseph , Polis, Michael A. , Rehm, Catherine A. , Gorelick, Robert , Piatak, Michael , Keele, Brandon F. , Kearney, Mary F. , Coffin, John M. , Hughes, Stephen H. , Mellors, John W. and Maldarelli, Frank
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Reservoirs of infectious HIV-1 persist despite years of combination antiretroviral therapy and make curing HIV-1 infections a major challenge. Most of the proviral DNA resides in CD4⁺T cells. Some of these CD4⁺T cells are clonally expanded; most of the proviruses are defective. It is not known if any of the clonally expanded cells carry replication...
Alternative Titles
Full title
Clonally expanded CD4⁺ T cells can produce infectious HIV-1 in vivo
Authors, Artists and Contributors
Author / Creator
Sobolewski, Michele D.
Fyne, Elizabeth
Shao, Wei
Spindler, Jonathan
Hattori, Junko
Anderson, Elizabeth M.
Watters, Sarah A.
Hill, Shawn
Wu, Xiaolin
Wells, David
Su, Li
Luke, Brian T.
Halvas, Elias K.
Besson, Guillaume
Penrose, Kerri J.
Yang, Zhiming
Kwan, Richard W.
Van Waes, Carter
Uldrick, Thomas
Citrin, Deborah E.
Kovacs, Joseph
Polis, Michael A.
Rehm, Catherine A.
Gorelick, Robert
Piatak, Michael
Keele, Brandon F.
Kearney, Mary F.
Coffin, John M.
Hughes, Stephen H.
Mellors, John W.
Maldarelli, Frank
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4763755
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4763755
Other Identifiers
ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.1522675113
