8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritog...
8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Oxidative stress and mitochondrial dysfunction are implicated in aging-related neurodegenerative disorders. 8-Oxoguanine (8-oxoG), a common oxidised base lesion, is often highly accumulated in brains from patients with neurodegenerative disorders. MTH1 hydrolyses 8-oxo-2′-deoxyguanosine triphosphate (8-oxo-dGTP) to 8-oxo-dGMP and pyrophosphate in n...
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8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4766534
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4766534
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep22086
