Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer
Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Key Points
Prostate cancer pathogenesis is dependent on signalling through the steroid nuclear hormone androgen receptor (AR), which is activated after binding of the androgen ligand testosterone or dihydrotestosterone. Ligand-bound AR translocates to the nucleus, where it serves to induce or repress gene expression through binding to chromatin...
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Full title
Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4771416
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4771416
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ISSN
1474-175X
E-ISSN
1474-1768
DOI
10.1038/nrc4016