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Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer

Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4771416

Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer

About this item

Full title

Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer

Publisher

London: Nature Publishing Group UK

Journal title

Nature reviews. Cancer, 2015-12, Vol.15 (12), p.701-711

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Key Points
Prostate cancer pathogenesis is dependent on signalling through the steroid nuclear hormone androgen receptor (AR), which is activated after binding of the androgen ligand testosterone or dihydrotestosterone. Ligand-bound AR translocates to the nucleus, where it serves to induce or repress gene expression through binding to chromatin...

Alternative Titles

Full title

Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4771416

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4771416

Other Identifiers

ISSN

1474-175X

E-ISSN

1474-1768

DOI

10.1038/nrc4016

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