Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins...
Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Neurodegenerative diseases (NDs) are often associated with the presence of misfolded protein inclusions. The chaperone HSPB8 is upregulated in mice, the human brain and muscle structures affected during NDs progression. HSPB8 exerts a potent pro-degradative activity on several misfolded proteins responsible for familial NDs forms. Here, we demonstr...
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Full title
Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4785366
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4785366
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep22827
