The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
About this item
Full title
Author / Creator
Zhang, Ke , Donnelly, Christopher J. , Haeusler, Aaron R. , Grima, Jonathan C. , Machamer, James B. , Steinwald, Peter , Daley, Elizabeth L. , Miller, Sean J. , Cunningham, Kathleen M. , Vidensky, Svetlana , Gupta, Saksham , Thomas, Michael A. , Hong, Ingie , Chiu, Shu-Ling , Huganir, Richard L. , Ostrow, Lyle W. , Matunis, Michael J. , Wang, Jiou , Sattler, Rita , Lloyd, Thomas E. and Rothstein, Jeffrey D.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The hexanucleotide repeat expansion (HRE) GGGGCC (G
4
C
2
) in
C9orf72
is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Recent studies support an HRE RNA gain-of-function mechanism of neurotoxicity, and we previously identified protein interactors for the G
4
C
2
RNA in...
Alternative Titles
Full title
The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
Authors, Artists and Contributors
Author / Creator
Donnelly, Christopher J.
Haeusler, Aaron R.
Grima, Jonathan C.
Machamer, James B.
Steinwald, Peter
Daley, Elizabeth L.
Miller, Sean J.
Cunningham, Kathleen M.
Vidensky, Svetlana
Gupta, Saksham
Thomas, Michael A.
Hong, Ingie
Chiu, Shu-Ling
Huganir, Richard L.
Ostrow, Lyle W.
Matunis, Michael J.
Wang, Jiou
Sattler, Rita
Lloyd, Thomas E.
Rothstein, Jeffrey D.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4800742
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4800742
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature14973
