NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
NEK7, a member of the NIMA-related kinase family, is identified as a regulator of NLRP3 inflammasome oligomerization and activation; NEK7 functions downstream of potassium efflux in a manner that is independent of its kinase activity.
NEK7 mediates NLRP3 inflammasome activation
The NLRP3 inflammasome, a critical component of the innate immune...
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Full title
NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4810788
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4810788
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature16959
