Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genom...
Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Precise genome-editing relies on the repair of sequence-specific nuclease-induced DNA nicking or double-strand breaks (DSBs) by homology-directed repair (HDR). However, nonhomologous end-joining (NHEJ), an error-prone repair, acts concurrently, reducing the rate of high-fidelity edits. The identification of genome-editing conditions that favor HDR...
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Full title
Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4814844
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4814844
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep23549
