TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD
TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD
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Publisher
United States: American Association for the Advancement of Science
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Language
English
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United States: American Association for the Advancement of Science
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Contents
Cytoplasmic aggregation of TDP-43, accompanied by its nuclear clearance, is a key common pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD). However, a limited understanding of this RNA-binding protein (RBP) impedes the clarification of pathogenic mechanisms underlying TDP-43 proteinopathy. In contrast to R...
Alternative Titles
Full title
TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4825810
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4825810
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aab0983
