Stochastic activation of a DNA damage response causes cell-to-cell mutation rate variation
Stochastic activation of a DNA damage response causes cell-to-cell mutation rate variation
About this item
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Author / Creator
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
United States: American Association for the Advancement of Science
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Scope and Contents
Contents
Cells rely on the precise action of proteins that detect and repair DNA damage. However, gene expression noise causes fluctuations in protein abundances that may compromise repair. For the Ada protein in Escherichia coli, which induces its own expression upon repairing DNA alkylation damage, we found that undamaged cells on average produce one Ada...
Alternative Titles
Full title
Stochastic activation of a DNA damage response causes cell-to-cell mutation rate variation
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4827329
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4827329
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aac9786
