Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects
Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
New evidence that human telomerase RNA (hTR) degradation by EXOSC10 or DCP2 and XRN1 reduces telomerase activity when dyskerin is compromised suggests that RNA decay pathways may provide future therapeutic targets for telomere biology disorders.
Mutations in the human telomerase RNA component (hTR), the telomerase ribonucleoprotein component dys...
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Full title
Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4830462
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4830462
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.3184
