The spliceosome is a therapeutic vulnerability in MYC-driven cancer
The spliceosome is a therapeutic vulnerability in MYC-driven cancer
About this item
Full title
Author / Creator
Hsu, Tiffany Y.-T. , Simon, Lukas M. , Neill, Nicholas J. , Marcotte, Richard , Sayad, Azin , Bland, Christopher S. , Echeverria, Gloria V. , Sun, Tingting , Kurley, Sarah J. , Tyagi, Siddhartha , Karlin, Kristen L. , Dominguez-Vidaña, Rocio , Hartman, Jessica D. , Renwick, Alexander , Scorsone, Kathleen , Bernardi, Ronald J. , Skinner, Samuel O. , Jain, Antrix , Orellana, Mayra , Lagisetti, Chandraiah , Golding, Ido , Jung, Sung Y. , Neilson, Joel R. , Zhang, Xiang H.-F. , Cooper, Thomas A. , Webb, Thomas R. , Neel, Benjamin G. , Shaw, Chad A. and Westbrook, Thomas F.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Splicing factors such as BUD31 are identified in a synthetic-lethal screen with cells overexpressing the transcription factor MYC; oncogenic MYC leads to an increase in pre-mRNA synthesis, and spliceosome inhibition impairs the growth and tumorigenicity of MYC-dependent breast cancers, suggesting that spliceosome components may be potential therape...
Alternative Titles
Full title
The spliceosome is a therapeutic vulnerability in MYC-driven cancer
Authors, Artists and Contributors
Author / Creator
Simon, Lukas M.
Neill, Nicholas J.
Marcotte, Richard
Sayad, Azin
Bland, Christopher S.
Echeverria, Gloria V.
Sun, Tingting
Kurley, Sarah J.
Tyagi, Siddhartha
Karlin, Kristen L.
Dominguez-Vidaña, Rocio
Hartman, Jessica D.
Renwick, Alexander
Scorsone, Kathleen
Bernardi, Ronald J.
Skinner, Samuel O.
Jain, Antrix
Orellana, Mayra
Lagisetti, Chandraiah
Golding, Ido
Jung, Sung Y.
Neilson, Joel R.
Zhang, Xiang H.-F.
Cooper, Thomas A.
Webb, Thomas R.
Neel, Benjamin G.
Shaw, Chad A.
Westbrook, Thomas F.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4831063
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4831063
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature14985
