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Reference EntriesFull Text
Neel, Benjamin G
Journal title:American Men & Women of Science : A Biographical Directory of Today’s Leaders in Physical, Biological and Related Sciences: MEL-OCK, 2022, p.8227-8227
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Reference EntriesFull Text
Neel, Benjamin G
Journal title:American Men & Women of Science : A Biographical Directory of Today’s Leaders in Physical, Biological and Related Sciences: MEN-OFT, 2021, p.8200-8200
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ArticlesPeer ReviewedFull Text
The current state of the art and future trends in RAS-targeted cancer therapies
Author / Creator:Punekar, Salman R. ; Velcheti, Vamsidhar ; Neel, Benjamin G. ; Wong, Kwok-Kin
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Clinical oncology, 2022-10, Vol.19 (10), p.637-655
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Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma
Author / Creator:Zhang, Shuang ; Dolgalev, Igor ; Zhang, Tao ; Ran, Hao ; Levine, Douglas A. ; Neel, Benjamin G.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-11, Vol.10 (1), p.5367-16, Article 5367
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ArticlesPeer ReviewedFull Text
NMR-based functional profiling of RASopathies and oncogenic RAS mutations
Author / Creator:Smith, Matthew J. ; Neel, Benjamin G. ; Ikura, Mitsuhiko
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-03, Vol.110 (12), p.4574-4579
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ArticlesPeer ReviewedFull Text
The tyrosine phosphatase Shp2 (PTPN11) in cancer
Author / Creator:Chan, Gordon ; Kalaitzidis, Demetrios ; Neel, Benjamin G.
Publisher:Boston: Springer US
Journal title:Cancer and metastasis reviews, 2008-06, Vol.27 (2), p.179-192
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ArticlesPeer ReviewedFull Text
Selective and noncovalent targeting of RAS mutants for inhibition and degradation
Author / Creator:Teng, Kai Wen ; Tsai, Steven T. ; Hattori, Takamitsu ; Fedele, Carmine ; Koide, Akiko ; Yang, Chao ; Hou, Xuben ; Zhang, Yingkai ; Neel, Benjamin G. ; O’Bryan, John P. ; Koide, Shohei
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-05, Vol.12 (1), p.2656-2656, Article 2656
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ArticlesPeer ReviewedFull Text
The spliceosome is a therapeutic vulnerability in MYC-driven cancer
Author / Creator:Hsu, Tiffany Y.-T. ; Simon, Lukas M. ; Neill, Nicholas J. ; Marcotte, Richard ; Sayad, Azin ; Bland, Christopher S. ; Echeverria, Gloria V. ; Sun, Tingting ; Kurley, Sarah J. ; Tyagi, Siddhartha ; Karlin, Kristen L. ; Dominguez-Vidaña, Rocio ; Hartman, Jessica D. ; Renwick, Alexander ; Scorsone, Kathleen ; Bernardi, Ronald J. ; Skinner, Samuel O. ; Jain, Antrix ; Orellana, Mayra ; Lagisetti, Chandraiah ; Golding, Ido ; Jung, Sung Y. ; Neilson, Joel R. ; Zhang, Xiang H.-F. ; Cooper, Thomas A. ; Webb, Thomas R. ; Neel, Benjamin G. ; Shaw, Chad A. ; Westbrook, Thomas F.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2015-09, Vol.525 (7569), p.384-388
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ArticlesPeer ReviewedFull Text
Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation
Author / Creator:Tsutsumi, Ryouhei ; Ueberheide, Beatrix ; Liang, Feng-Xia ; Neel, Benjamin G. ; Sakai, Ryuichi ; Saito, Yoshiro
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-04, Vol.15 (1), p.2843-2843, Article 2843
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ArticlesPeer ReviewedFull Text
Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site
Author / Creator:Mazhab-Jafari, Mohammad T. ; Marshall, Christopher B. ; Smith, Matthew J. ; Gasmi-Seabrook, Geneviève M. C. ; Stathopulos, Peter B. ; Inagaki, Fuyuhiko ; Kay, Lewis E. ; Neel, Benjamin G. ; Ikura, Mitsuhiko
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-05, Vol.112 (21), p.6625-6630
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ArticlesPeer ReviewedFull Text
Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor
Author / Creator:Peled, Michael ; Tocheva, Anna S. ; Sandigursky, Sabina ; Nayak, Shruti ; Philips, Elliot A. ; Nichols, Kim E. ; Strazza, Marianne ; Azoulay-Alfaguter, Inbar ; Askenazi, Manor ; Neel, Benjamin G. ; Pelzek, Adam J. ; Ueberheide, Beatrix ; Mor, Adam
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-01, Vol.115 (3), p.E468-E477
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ArticlesPeer ReviewedFull Text
Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome
Author / Creator:Lee, Yong-Seok ; Ehninger, Dan ; Zhou, Miou ; Oh, Jun-Young ; Kang, Minkyung ; Kwak, Chuljung ; Ryu, Hyun-Hee ; Butz, Delana ; Araki, Toshiyuki ; Cai, Ying ; Balaji, J ; Sano, Yoshitake ; Nam, Christine I ; Kim, Hyong Kyu ; Kaang, Bong-Kiun ; Burger, Corinna ; Neel, Benjamin G ; Silva, Alcino J
Publisher:New York: Nature Publishing Group US
Journal title:Nature neuroscience, 2014-12, Vol.17 (12), p.1736-1743
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ArticlesPeer ReviewedFull Text
Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome–associated PTPN11 mutation
Author / Creator:Marin, Talita M. ; Keith, Kimberly ; Davies, Benjamin ; Conner, David A. ; Guha, Prajna ; Kalaitzidis, Demetrios ; Wu, Xue ; Lauriol, Jessica ; Wang, Bo ; Bauer, Michael ; Bronson, Roderick ; Franchini, Kleber G. ; Neel, Benjamin G. ; Kontaridis, Maria I.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2011-03, Vol.121 (3), p.1026-1043
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ArticlesPeer ReviewedFull Text
Off‐target inhibition by active site‐targeting SHP2 inhibitors
Author / Creator:Tsutsumi, Ryouhei ; Ran, Hao ; Neel, Benjamin G.
Publisher:England: John Wiley & Sons, Inc
Journal title:FEBS open bio, 2018-09, Vol.8 (9), p.1405-1411
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ArticlesPeer ReviewedFull Text
Phenotypic heterogeneity and instability of human ovarian tumor-initiating cells
Author / Creator:Stewart, Jocelyn M ; Shaw, Patricia A ; Gedye, Craig ; Bernardini, Marcus Q ; Neel, Benjamin G ; Ailles, Laurie E
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-04, Vol.108 (16), p.6468-6473
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ArticlesPeer ReviewedFull Text
Next-generation sequencing identifies rare variants associated with Noonan syndrome
Author / Creator:Chen, Peng-Chieh ; Yin, Jiani ; Yu, Hui-Wen ; Yuan, Tao ; Fernande, Minerva ; Yung, Christina K. ; Trinh, Quang M. ; Peltekova, Vanya D. ; Reid, Jeffrey G. ; Tworog-Dube, Erica ; Morgan, Margaret B. ; Muzny, Donna M. ; Stein, Lincoln ; McPherson, John D. ; Roberts, Amy E. ; Gibbs, Richard A. ; Neel, Benjamin G. ; Kucherlapati, Raju
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (31), p.11473-11478
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ArticlesPeer ReviewedFull Text
Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2
Author / Creator:Tsutsumi, Ryouhei ; Harizanova, Jana ; Stockert, Rabea ; Schröder, Katrin ; Bastiaens, Philippe I. H. ; Neel, Benjamin G.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-09, Vol.8 (1), p.466-14, Article 466
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ArticlesPeer ReviewedFull Text
Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress
Author / Creator:Delibegovic, Mirela ; Zimmer, Derek ; Kauffman, Caitlin ; Rak, Kimberly ; Hong, Eun-Gyoung ; Cho, You-Ree ; Kim, Jason K. ; Kahn, Barbara B. ; Neel, Benjamin G. ; Bence, Kendra K.
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2009-03, Vol.58 (3), p.590-599
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Newsletter articlesFull Text
Rhode Island Hospital, Univ Health Network, Yang Wentian and Neel Benjamin G File WIPO Patent Application for Hedgehog Pathway Inhibition for Cartilage Tumor and Metachondromatosis Treatment
Publisher:New Delhi: Pedia Content Solutions Pvt. Ltd
Journal title:Global IP News. Medical Patent News, 2013
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Computational modeling of ovarian cancer dynamics suggests optimal strategies for therapy and screening
Author / Creator:Gu, Shengqing ; Lheureux, Stephanie ; Sayad, Azin ; Cybulska, Paulina ; Hogen, Liat ; Vyarvelska, Iryna ; Tu, Dongsheng ; Parulekar, Wendy R. ; Nankivell, Matthew ; Kehoe, Sean ; Chi, Dennis S. ; Levine, Douglas A. ; Bernardini, Marcus Q. ; Rosen, Barry ; Oza, Amit ; Brown, Myles ; Neela, Benjamin G.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-06, Vol.118 (25), p.1-12
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Neel, Benjamin G

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Neel, Benjamin G

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The current state of the art and future trends in RAS-targeted cancer therapies

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Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma

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NMR-based functional profiling of RASopathies and oncogenic RAS mutations

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The tyrosine phosphatase Shp2 (PTPN11) in cancer

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Selective and noncovalent targeting of RAS mutants for inhibition and degradation

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The spliceosome is a therapeutic vulnerability in MYC-driven cancer

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Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation

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Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

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Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor

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Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome

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Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome–associated PTPN11 mutation

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Off‐target inhibition by active site‐targeting SHP2 inhibitors

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Phenotypic heterogeneity and instability of human ovarian tumor-initiating cells

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Next-generation sequencing identifies rare variants associated with Noonan syndrome

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Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2

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Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress

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Rhode Island Hospital, Univ Health Network, Yang Wentian and Neel Benjamin G File WIPO Patent Application for Hedgehog Pathway Inhibition for Cartilage Tumor and Metachondromatosis Treatment

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Computational modeling of ovarian cancer dynamics suggests optimal strategies for therapy and screening

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