Integrin α11β1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-...
Integrin α11β1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-small cell lung cancer
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Author / Creator
Navab, R , Strumpf, D , To, C , Pasko, E , Kim, K S , Park, C J , Hai, J , Liu, J , Jonkman, J , Barczyk, M , Bandarchi, B , Wang, Y H , Venkat, K , Ibrahimov, E , Pham, N-A , Ng, C , Radulovich, N , Zhu, C-Q , Pintilie, M , Wang, D , Lu, A , Jurisica, I , Walker, G C , Gullberg, D and Tsao, M-S
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Integrin α11β1 is a stromal cell-specific receptor for fibrillar collagens and is overexpressed in carcinoma-associated fibroblasts (CAFs). We have investigated its direct role in cancer progression by generating severe combined immune deficient (SCID) mice deficient in integrin α11 (α11) expression. The growth of A549 lung adenocarcinoma cells and...
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Full title
Integrin α11β1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-small cell lung cancer
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4833874
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4833874
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/onc.2015.254
