Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease i...
Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Misfolding of proteins in the biosynthetic pathway in neurons may cause disturbed protein homeostasis and neurodegeneration. The prion protein (PrP
C
) is a GPI-anchored protein that resides at the plasma membrane and may be misfolded to PrP
Sc
leading to prion diseases. We show that a deletion in the C-terminal domain of PrP
C
(P...
Alternative Titles
Full title
Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4847012
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4847012
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep24970
