Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat...
Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia
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Author / Creator
Khalife, J , Radomska, H S , Santhanam, R , Huang, X , Neviani, P , Saultz, J , Wang, H , Wu, Y-Z , Alachkar, H , Anghelina, M , Dorrance, A , Curfman, J , Bloomfield, C D , Medeiros, B C , Perrotti, D , Lee, L J , Lee, R J , Caligiuri, M A , Pichiorri, F , Croce, C M , Garzon, R , Guzman, M L , Mendler, J H and Marcucci, G
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
High levels of
microRNA-155
(
miR-155
) are associated with poor outcome in acute myeloid leukemia (AML). In AML,
miR-155
is regulated by NF-κB, the activity of which is, in part, controlled by the NEDD8-dependent ubiquitin ligases. We demonstrate that MLN4924, an inhibitor of NEDD8-activating enzyme presently being evaluated in c...
Alternative Titles
Full title
Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia
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Primary Identifiers
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4868182
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4868182
Other Identifiers
ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/leu.2015.106
